Vape and e-cigarette retailers in St. Louis must hold a Missouri tobacco/vapor permit, verify customer ages under Mo. §407.926, and follow city zoning and business license requirements under Title XI.
Missouri regulates vapor product retailers through the Department of Revenue tobacco licensing program, with vapor products formally added to age-21 enforcement under Mo. §407.926 effective 2024. St. Louis layers local business licensing (Graduated Business License under Title XI) and zoning conformance for any vape-specialty retailer. The city does not currently impose flavor restrictions, but the Health Department supports retailer education on PMTA-compliant inventories under federal FDA enforcement. Retailers must keep purchase records, prevent sales to minors, and comply with federal Synar amendment compliance checks coordinated by Missouri DHSS. Online and mail-order delivery into Missouri must verify age at delivery.
Selling vapor products without a Missouri permit, or to underage buyers, results in fines, license suspension, and possible criminal misdemeanor charges under state law.
See how St. Louis's vape retail rules rules stack up against other locations.
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