Mississippi's Medical Cannabis Act allowed municipalities and counties to opt out. Several DeSoto County cities opted out; dispensaries that do operate must meet 1,000-foot buffers from schools, churches, and child-care centers under Miss. Code §41-137-35.
Miss. Code §41-137-29 allowed each county and municipality a 90-day window after May 2, 2022 to opt out of hosting medical cannabis establishments. Within DeSoto County, several municipalities exercised the opt-out by resolution, and unincorporated DeSoto County voters also weighed in via referendum petitions under the statute. Where dispensaries are permitted, Miss. Code §41-137-35 imposes a statewide 1,000-foot buffer from the property line of any school, church, or licensed child-care center (measurable by city ordinance as short as 500 feet by local consent). Dispensaries require both a MSDH state license and local zoning/use approval — typically permitted only in C-3 or C-4 commercial zones with site-plan review. Patient card verification, surveillance cameras retained 30 days, and seed-to-sale tracking are mandatory. Operating hours are capped by state rule.
Operating without state license: felony plus facility closure. Buffer violation: license denial or revocation. Selling to non-patients: felony charges. Security or tracking violation: MSDH fines $1,000 to $10,000 plus license action.
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See how Desoto County's dispensary zoning rules stack up against other locations.
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