O'Fallon, MO Cannabis Regulations: Dispensary Zoning (2026)

245 caps marijuana dispensary facilities citywide at ten and bars any of them from the Downtown Overlay District, regardless of underlying zoning. Before seeking a license from the Missouri Department of Health and Senior Services, an applicant must obtain a Site Review Permit confirming the site meets the City's zoning and location standards; that preliminary approval expires one year after issuance if a State license has not followed. Once the State license is in hand, the operator applies for a City business license covering the approved operating, security and floor plans.

Every facility must carry security cameras covering each entrance and the interior and exterior, retain surveillance video at least ninety days, keep salable inventory in a locked, secured area, install a permanently affixed safe for on-site currency, and maintain a monitored alarm system. The dispensary must give the Chief of Police a named on-site contact reachable by phone, email and fax. No one under eighteen may enter a cultivation, testing or manufacturing facility, and dispensaries must post that age restriction at the entrance. Marijuana sold on-site must be sealed in labeled packaging, the sales counter must be walled off from the waiting area, and no product may be visible from outside through glass or windows. Signs for any marijuana use must comply with Chapter 410's sign regulations and sit on the same premises as the facility itself.